Cardio-Renal Physiology Laboratory

Mission

The mission of the App State NCRC Cardio-Renal Physiology (CRP) Laboratory is to investigate hormonal regulation of sodium balance and blood pressure homeostasis in health and disease. 

The CRP Lab provides insight into renal and cardiovascular whole animal integrative physiology. The CRP Lab examines the role of the renin angiotensin aldosterone system (RAAS) on renal sodium handling, plasma volume and blood pressure homeostasis in pregnancy.

This research will provide the field of women’s health with base information necessary to better understand the pathologies of pregnancy such as preeclampsia and intrauterine growth restriction that are associated with volume contraction and dysregulation of blood pressure.


News and Research

Proteinase-activated receptor-2 (PAR2) on blood pressure and electrolyte handling in the late pregnant rat

New findings: What is the central question of this study? Pregnancy requires marked renal sodium and potassium retention and cumulative plasma vo...

The Angiotensin Type 1 Receptor Antagonist Losartan Prevents Ovariectomy-Induced Cognitive Dysfunction and Anxiety-Like Behavior in Long Evans Rats

Women who have bilateral oophorectomies prior to the age of natural menopause are at increased risk of developing mild cognitive decline, dementia, an...

Renal T cell infiltration occurs despite attenuation of development of hypertension with hydralazine in Envigo's female Dahl rat maintained on a low-Na + diet

Many studies have suggested that renal T cell infiltration contributes to the pathogenesis of salt-sensitive hypertension. To investigate this mechani...

Adaptive remodeling of renal Na+ and K+ transport during pregnancy

Purpose of review: Renal ion transport undergoes dramatic changes during the course of gestation. These adaptations are necessary to meet the dyn...

Salt-sensitive (Rapp) rats from Envigo spontaneously develop accelerated hypertension independent of ovariectomy on a low-sodium diet

Inbred salt-sensitive (SS) rats developed by John Rapp and distributed by Harlan (SS/JrHsd) were shown to model ovariectomy-induced hypertension becau...