Publications, 2011-2017

1. Knab AM, Shanely RA, Henson DA, Jin F, Heinz SA, Austin MD, Nieman DC. Influence of quercetin supplementation on disease risk factors in community-dwelling adults. J Am Diet Assoc 111:542-549, 2011.

2. Broman-Fulks JJ, Canu WH, Trout KL, Nieman DC. The effects of quercetin supplementation on cognitive functioning in a community sample: a randomized, placebo-controlled trial. Therap Adv Psychopharmacol 2012: 2(4) 131 –138; DOI: 10.1177/2045125312445894.

3. McAnulty SR, Nieman DC, McAnulty LS, Lynch WS, Jin F, Henson DA. Effect of mixed flavonoids, n-3 fatty acids, and vitamin C on oxidative stress and antioxidant capacity before and after intense cycling. Int J Sport Nutr Exerc Metab 21:328-337, 2011.

4. Walsh NP, Gleeson M, Pyne DB, Nieman DC, Dhabhar FS, Shephard RJ, Oliver SJ, Bermon S, Kajeniene A. Position statement. Part two: Maintaining immune health. Exerc Immunol Rev 17:64-103, 2011.

5. Nieman DC. Moderate exercise improves immunity and decreases illness rates. Am J Lifestyle Med 5(4):338-345, 2011.

6. McAnulty LS, Nieman DC, Dumke CL, Shooter L, Henson DA, Utter AC, Milne G, McAnulty SR. Effect of blueberry ingestion on natural killer cell counts, oxidative stress, and inflammation prior to and after 2.5 h of running. Appl Physiol Nutr Metab 36:976-984, 2011.

7. Nieman DC, Henson DA, Austin MD, Sha W. Upper respiratory tract infection is reduced in physically fit and active adults. Br J Sports Med 45:987-992, 2011.

8. Knab AM, Shanely RA, Jin F, Austin MD, Sha W, Nieman DC. Quercetin with vitamin C and niacin does not affect body mass or composition. Appl Physiol Nutr Metab 36(3):331-338, 2011.

9. Nieman DC, Stear SJ, Castell LM, Burke LM. A-Z of nutritional supplements: dietary supplements, sports nutrition foods and ergogenic aids for health and performance: part 15, flavonoids. Br J Sports Med 44(16):1202-1205, 2010.

10. Scherr J, Nieman DC, Schuster T, Habermann J, Rank M, Braun S, Pressier A, Wolfarth B, Halle M. Non-alcoholic beer reduces inflammation and the incidence of upper respiratory tract infections following The Munich Marathon: A randomized, controlled, double-blinded trial. Med Sci Sports Exerc 44:18-26, 2012.

11. Jin F, Nieman DC, Sha W, Qiu Y, Xie G, Jia W, Glahn RP, Rutzke MA, Shanely RA. Supplementation of milled chia seeds increases plasma ALA and EPA in post-menopausal women. Plant Hum Nutr 67:105-110, 2012.

12. Shanely RA, Nieman DC, Henson DA, Jin F, Knab A, Sha W. Perceived fitness is predictive of decreased inflammation and oxidative stress. Scand J Med Sci Sports doi: 10.1111/j.1600- 0838.2011.01373.x, 2011.

13. Nieman DC. Clinical implications of exercise immunology for the practicing physician. The Year Book for Sports Medicine. St. Louis: Mosby, 2011, pp. xv-xxiii.

14. Konrad M, Nieman DC, Henson DA, Kennerly K, Jin F, Wallner-Liebmann SJ. The acute effect of ingesting a quercetin-based supplement on exercise-induced inflammation and immune changes in runners. Int J Sport Nutr Exerc Metab 21:338-346, 2011.

15. Garber CE, Blissmer B, Deschenes MR, Franklin BA, Lamonte MJ, Lee I-M, Nieman DC, Swain DP. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc 43:1334-1359, 2011.

16. Nieman DC, Konrad M, Henson DA, Kennerly K, Shanely RA, Wallner-Liebmann SJ. Variance in the acute inflammatory response to prolonged cycling is linked to exercise intensity. J Interferon Cytokine Res 32:12-17, 2012.

17. Combs M, Canu W, Broman-Fulks J, Rocheleau C, Nieman DC. Perceived stress and attention-deficit/hyperactivity disorder symptoms in adults. J Atten Dis DOI: 10.1177/1087054712459558, 2012.

18. Root MM, Martin AE, Ratliff MD, Williams HD, Nieman DC. Quercetin dosing improves endothelial function in younger but not older healthy middle-aged adults. Nutrients 4(1):29-41, 2012.

19. Nieman DC, Gillitt N, Jin F, Henson DA, Kennerly K, Shanely A, Ore B, Su MM, Schwartz S. Chia seed supplementation and disease risk factors in overweight women: a metabolomics investigation. J Alt Comp Med 18(7):700-708, 2012.

20. Kappus R, Curry CD, McAnulty SR, Welsh J, Morris DM, Nieman DC, Soukup JT, Collier SR. The effects of a multi-flavonoid supplement on vascular and hemodynamic parameters following acute exercise. Oxid Med Cell Longevity doi:10.1155/2011/210798, 2011.

21. Nieman DC, Austin M, Dew D, Utter AC. Validation of COSMED’s Quark CPET and mixing chamber system during exercise. Res Sports Med 21:136–145, 2013.

22. Nieman DC. Clinical implications of exercise immunology. J Sport Health Sci 1:12-17, 2012.

23. Knab AM, Shanely RA, Corbin K, Jin F, Sha W, Nieman DC. A 45-minute vigorous exercise bout increases metabolic rate for 14 hours. Med Sci Sports Exerc. 43:1643-1648, 2011.

24. Nieman DC. Exercise, nutrition, and immune function, IN: The IOC Encyclopedia of Sports Nutrition (Maughn R, editor). Hoboken, NJ: Wiley, 2014, pp. 478-489.

25. Nieman DC. Exercise and respiratory infection. In: Rippe J (ed). Lifestyle Medicine (2nd edition). London: Taylor and Francis Group/CRC Press, 2013, pp. 597-604. Section Editor, Part X (Immunology and Infectious Disease.

26. Nieman DC. Immunonutrition support for athletes: does it work? IN: Nutrition and Performance in Sport. Paris: Institut National du Sport, de l’Expertise et de la Performance, pp. 91- 102, 2012.

27. Nieman DC, Gillitt ND, Henson DA, Sha W, Shanely A, Knab AM, Cialdella-Kam L, Jin F. Bananas as an energy source during exercise: a metabolomics approach. PLoS One 7(5):e37479, 2012.

28. Nieman DC, Dew D, Krasen PG. Gender difference in the acute influence of a 2-hour run on arterial stiffness in trained runners. Res Sports Med 21:66-77, 2013.

29. Cialdella-Kam L, Nieman DC, Sha W, Meaney MP, Knab AM, Shanley RA. Dose-response to long-term quercetin supplementation on metabolite and quercetin conjugate profile in adults. Br J Nutr 109, 1923–1933, 2013.

30. Meeusen R, Duclos M, Foster C, Fry A, Gleeson M, Nieman DC, Raglin J, Rietjens G, Steinacker J, Urhausen A. Prevention, diagnosis and treatment of the overtraining syndrome. Joint consensus statement of the European College of Sport Science (ECSS) and the American College of Sports Medicine (ACSM). Med Sci Sports Exerc. 45(1):186-205, 2013.

31. Knab AM, Nieman DC, Broman-Fulks JJ, Canu WH, Sha W. Exercise frequency is related to psychopathology but not neurocognitive function. Med Sci Sports Exerc. 44:1395-1400, 2012.

32. Nieman DC, Laupheimer M, Ranchordas MK, Burke LM, Stear S, Castell LM. A–Z of nutritional supplements: dietary supplements, sports nutrition foods and ergogenic aids for health and performance Part 33. Br J Sports Med 46:618-620, 2012.

33. LaVoy ECP, Nieman DC, Henson DA, Shanely RA, Knab AM, Cialdella-Kam L, Simpson RJ. Latent cytomegalovirus infection does not alter innate immune function in response to a 75-km cycling time trial. Eur J Appl Physiol 113:2629-2635, 2013.

34. Nieman DC, Cialdella-Kam L, Knab AM, Shanely RA. Influence of red pepper spice and turmeric on inflammation and oxidative stress in overweight females: a metabolomics approach. Plant Hum Nutr 67:415-421, 2012.

35. Luo B, Yang Y, Nieman DC, Zhang Y, Wang J, Wang R, Chen P. A 6-week diet and exercise intervention alters metabolic syndrome risk factors in obese Chinese children aged 11-13 years. J Sport Health Sci 2:236-241, 2013.

36. Shanely RA, NiemanDC, Knab,AM, Gillitt ND, Meaney MP, Jin F, Sha, W, Cialdella-Kam L. Influence of vitamin D mushroom powder supplementation on exercise-induced muscle damage in vitamin D insufficient high school athletes. J Sport Sci J Sport Sci 32:670-679, 2014.

37. Nieman DC, Gillitt ND, Knab AM, Shanely RA, Pappan KL, Jin F, Lila MA. Influence of a polyphenol-enriched protein powder on exercise-induced inflammation and oxidative stress in athletes: a randomized trial using a metabolomics approach. PLoS ONE 8(8): e72215, 2013.

38. Knab AM, Nieman DC, Gillitt ND, Shanely RA, Cialdella-Kam L, Henson DA, Sha W.Effects of a flavonoid-rich juice on inflammation, oxidative stress, and immunity in elite swimmers: a metabolomics-based approach. Int J Sport Nutr Exerc Metab 23:150-160, 2013.

39. Combs M, Canu W, Broman-Fulks J, Rocheleau C, Nieman DC. Impact of attention-deficit/hyperactivity disorder symptoms on adults’ quality of life. Am J Orthopsych (in press).

40. Bailey SP, Nieman DC. Chronic fatigue syndrome. IN: ACSM’s Exercise Management for Persons with Chronic Conditions (4th edition). (In press).

41. Nieman DC, Shanely RA, Gillitt ND, Pappan KL, Lila MA. Serum metabolic signatures induced by a 3-day intensified exercise period persist after 14 hours of recovery in runners. J Prot Res 12:4577-4584, 2013.

42. Shanely RA, Nieman DC, Zwetsloot KA, Knab AM, Imagita H, Luo B, Davis B, Zubeldia JM. Evaluation of Rhodiola rosea supplementation on skeletal muscle damage and inflammation in runners following a competitive marathon. Brain Beh Immune 39:204-210, 2014.

43. Knab AM, Nieman DC, Gillitt ND, Shanely RA, Cialdella-Kam L, Henson DA, Sha W, Meaney MP. Effects of a freeze dried juice blend powder on exercise induced inflammation, oxidative stress, and immune function in cyclists. Appl Physiol Nutr Metab 39:381-385, 2014.

44. Luo B, Xiang D, Nieman DC, Chena P. Moderate exercise counters chronic stress-induced intestinal barrier dysfunction by enhancing antimicrobial defense. Brain Beh Immun 39:99-106, 2014.

45. Nieman DC, Luo B, Dreau D, Henson DA, Shanely RA, Dew D, Meaney MP. Immune and inflammation responses to a 3-day period of intensified running versus cycling. Brain Beh Immun Brain Beh Immun 39:180-185, 2014.

46. Konrad M, Nieman DC. Evaluation of quercetin as a countermeasure to exercise-induced physiologic stress. In: Anxtioxidants in Sports Nutrition. Boca Raton, FL: CRC Press, 2014.

47. Nieman DC, Gillitt ND, Shanely RA, Dew D, Meaney MP, Luo B. Vitamin D2 supplementation amplifies eccentric exercise-induced muscle damage in NASCAR pit crew athletes. Nutrients 6:63-75, 2013.

48. O’Connor A, Corbin KA, Nieman DC, Swick AG. A randomized, controlled trial to assess short-term black pepper consumption on 24-hour energy expenditure and substrate utilization. Funct Foods Health Dis 3(10) 377-388, 2013.

49. Nieman DC, Shanely RA, Luo B, Dustin D, Meaney MP, Sha W. A commercialized dietary supplement alleviates joint pain in community adults: a double-blind, placebo-controlled community trial. Nutr J 12:154, 2013.

50. Grabs V, Nieman DC, Haller B, Halle M, Scherr J. The effects of oral hydrolytic enzymes and flavonoids on inflammatory markers and coagulation after marathon running: study protocol for a randomized, double-blind, placebo-controlled trial. BMC Sports Sci Med Rehabil 22;6(1):8, 2014.

51. Lemley K, Nieman DC, Meyer BB. Fibromyalgia. IN: ACSM’s Exercise Management for Persons with Chronic Conditions (4th edition). (In press).

52. Arthur ST, Zwetsloot KA, Lawrence MM, Nieman DC, Lila MA, Grace MH, Howden R, Cooley ID, Tkach JF, Keith MD, Demick JL, Blanton SE, Greiner RS, Bradley AM, Davenport ME, Badmaev V, Shanely RA. Ajuga turkestanica increases Notch and Wnt signaling in aged skeletal muscle. Eur Rev Med Pharmacol Sci. 2014;18:2584-2592.

53. Shanely RA, Zwetsloot KA, Triplett NT, Meaney MP, Farris GE, Nieman DC. Human skeletal muscle biopsy procedures using the modified Bergström technique. J Vis Exp 2014;91:e51812.

54. Luo B, Xiang D, Nieman DC, Chen P. Hypoxia-inducible factor prolyl hydroxylase inhibition attenuates chronic stress induced intestinal barrier dysfunction. J Appl Physiol (under review).

55. Nieman DC, Shanely RA, Luo B, Meaney MP, Dew DA, Pappan KL. Metabolomics approach to assessing plasma 13- and 9-hydroxy-octadecadienoic acid responses to a 75-km cycling bout. Am J Physiol:Reg Integr Comp Physiol 2014;307:R68-74.

56. Nieman DC, Scherr J, Luo B, Meaney MP, Dreau D, Sha W, Dew DA, Henson D, Pappan KL. Influence of pistachios on performance and exercise-induced inflammation, oxidative stress, and immune dysfunction in athletes: a metabolomics-based approach. PLoS ONE 2014 Nov 19;9(11):e113725.

57. Scherr J, Haller B, Nieman DC, Lorenz E, Pressler A, Siegmund B, Wolfarth B, Halle M. Polyphenol supplementation improves cardiomyocyte recovery after marathon running: a doubleblind, randomized, placebo-controlled trial. Eur Heart J (under review).

58. Ahmed M, Henson DA, Sanderson M, Nieman DC, Gillitt ND, Lila MA. The protective effects of a polyphenol-enriched protein powder on exercise-induced susceptibility to virus infection. Phytother Res. 2014;28(12):1829-36.

59. Peake J, Gatta PD, Nieman DC. Cytokine expression and secretion by skeletal muscle cells: regulatory mechanisms, biological significance and exercise effects. Exerc Immunol Rev 2015;21:8-25.

60. Xie G, Ma X, Zhao A, Wang C, Zhang Y, Nieman D, Nicholson JK, Jia W, Bao Y, Jia W. The metabolite profiles of the obese population are gender-dependent. J Proteome Res. 2014;13:4062-73.

61. Ahmed M, Henson DA, Sanderson MC, Nieman DC, Zubeldia JM. Rhodiola rosea exerts anti-viral activity in athletes following a competitive marathon race. Frontiers Nutrition: Sport and Exercise Nutrition Front. Nutr. 2015;doi: 10.3389/fnut.2015.00024.

62. Beals K, Allison KF, Darnell M, Lovalekar M, Nieman DC, Baker R, Vodovotz Y, Lephart SM. The effects of tart cherry beverage on reducing exercise-induced muscle soreness. Isokinetics and Exercise Science 2017;25:53-63.

63. Nieman DC, Shanely RA, Zwetsloot KA, Meaney MP, Farris G. Ultrasonic assessment of exercise-induced change in skeletal muscle glycogen content. BMC Sports Sci Med Rehabil 7:9;2015, DOI 10.1186/s13102-015-0003-z.

64. Nieman DC, Gillitt ND, Meaney MP, Dew DA. No positive influence of ingesting chia seed oil on human running performance. Nutrients 2015;7:3666-3676.

65. Nieman DC. Flavonoids. IN: Castell LM, Stear SJ, Burke LM (editors). Nutritional Supplements in Sport, Exercise, and Health, An A-Z Guide. Oxford: Routledge (Taylor & Francis), 2015, pp. 121-125.

66. Nieman DC, Zwetsloot KA, Meaney MP, Lomiwes DD, Hurst SM, Hurst RD. Post-exercise skeletal muscle glycogen related to plasma cytokines and muscle IL-6 protein content, but not muscle mRNA expression. Frontiers in Nutrition: Sport and Exercise Nutrition 2015;2:27; doi: 10.3389/fnut.2015.00027.

67. Lu NT, Crespi CM, Liu NM, Vu JQ, Ahmadieh Y, Wu S, Lin S, McClune A, Durazo F, Saab S, Han S, Nieman DC, Beaven S, French SW. A phase i dose escalation study demonstrates quercetin safety and explores potential for bioflavonoid antivirals in patients with chronic hepatitis C. Phytother Res. 2016;30:160-168.

68. Nieman DC. Immunonutrition support for athletes: does it work? French National Institute of Sport, Expertise and Performance, 2015, pp. 105-118. 80324. Nieman DC, Gillitt ND, Sha W, Meaney MP, John C, Pappan KL, Kinchen JM. Metabolomics-based analysis of banana and pear ingestion on exercise performance and recovery. J Proteome Res 2015 Dec 4;14(12):5367-77.

69. Meaney MP, Nieman DC, Henson DA, Jiang Q, Wang FZ. Measuring granulocyte and monocyte phagocytosis and oxidative burst activity in human blood. J Vis Exp 2016 (115):e54264, doi:10.3791/54264.

70. Nieman DC, Meaney MP, John CS, Knagge KJ, Chen H. 9- and 13-hydroxy-octadecadienoic acids (9+13 HODE) are inversely related to granulocyte colony stimulating factor and IL-6 in runners after 2 h running. Brain Behav Immun. 2016;56:246-252.

71. Grabs V, Kersten A, Haller B, Nieman DC, Halle M, Scherr J. Rutoside and hydrolytic enzymes do not attenuate marathon-induced inflammation. Med Sci Sports Exerc (in press).

72. Nieman DC, Zwetsloot KA, Lomiwes DD, Meaney MP, Hurst RD. Muscle glycogen depletion following 75-km of cycling is not linked to increased muscle IL-6, IL-8, and MCP-1 mRNA expression and protein content. Front Physiol: Exerc Physiol 2016;7:431.

73. Cialdella-Kam L, Nieman DC, Knab AM, Shanely RA, Meaney MP, Jin F, Sha W, Ghosh S. A mixed flavonoid-fish oil supplement induces immune-enhancing and anti-inflammatory transcriptomic changes in adult obese and overweight women: a randomized, controlled trial. Nutrients 2016 May 11;8(5). pii: E277.

74. McBride ME, Meaney MP, John C, Nieman DC, Warin RF. Flow cytometric analysis of natural killer cell lytic activity in human whole blood. J Vis Exp 2017;121, e54779.

75. Clauss S, Scherr J, Hanley A, Schneider J, Klier I, Lackermair K, Vogeser M, Nieman DC, Halle M, Nickel T. Impact of polyphenols on physiological stress and cardiac burden in marathon runners – results from a sub-study of the BeMAGIC study. Applied Physiology, Nutrition, and Metabolism 2017;doi:10.1139/apnm-2016-0457.

76. Anderson JC, Nieman DC. Commentary: Diet quality—The Greeks had it right! Nutrients 2016 Oct 14;8(10). pii: E636.

77. Bermon S, Castell LM, Calder PC, Bishop NC, Blomstrand E, Mooren FC, Kruger K, Kavazis AN, Quindry JC, Senchina DS, Nieman DC, Gleeson M, Pyne DB, Kitic CM, Close GL, Larson-Meyer DE, Marcos A, Meydani SN, Wu D, Walsh NP, Nagatomi R. Consensus statement: Immunonutrition and exercise. Exerc Immunol Rev 2017;23:8-50.

78. Lackermair K, Scherr J, Waidhauser G, Methe H, Hoster E, Nieman DC, Hanley A, Clauss S, Halle M, Nickel T. Influence of polyphenol-rich diet on stress-induced Immunomodulation. Appl Physiol Nutr Metab 2017; (in press).

79. Shanely RA, Nieman DC, Perkins-Veazie P, Henson DA, Meaney MP, Knab AM, Cialdell-Kam L, Sha W. Comparison of watermelon and carbohydrate beverage on exercise-induced alterations in systemic inflammation, immune dysfunction, and plasma antioxidant capacity. Nutrients 2016;8:518; doi:10.3390/nu8080518.

80. Nieman DC, Sha W, Pappan KL. IL-6 linkage to exercise-induced shifts in lipid-related metabolites: A metabolomics-based analysis. J Proteome Res. 2017;16:970-977.

81. Nieman DC, Ramamoorthy S, Kay CD, Goodman CL, Capps CR, Shue ZL, Heyl N, Grace MH, Lila MA. Influence of ingesting a flavonoid-rich supplement on the human metabolome and concentration of urine phenolics. J Proteome Res (in press).

82. Nieman DC. Impact of nutrition on immune system recovery from heavy exertion: A metabolomics perspective. Nutrients 2017;9:513.

83. Nieman DC. The common cold is less common among the fit. ACSM Health & Fitness Journal 2017; (under review).

84. Cialdella-Kam L, Ghosh S, Meaney MP, Knab AM, Shanely RA, Nieman DC. Quercetin and green tea extract supplementation downregulates genes related to tissue inflammatory responses to a 12-week high fat-diet in mice. Nutrients 2017;9(7).