Renal NCC is unchanged in the midpregnant rat and decreased in the late pregnant rat despite avid renal Na+ retention
Apr 29, 2015
Pregnancy is characterized by plasma volume expansion due to Na(+) retention, driven by aldosterone. The aldosterone-responsive epithelial Na(+) chann...
Pregnant rats treated with a high-fat/prooxidant Western diet with ANG II and TNF-α are resistant to elevations in blood pressure and renal oxidative stress
Mar 25, 2015
Oxidative stress and inflammation are risk factors for hypertension in pregnancy. Here, we examined the 24-h mean arterial pressure (MAP) via telemetr...
Renal epithelial sodium channel is critical for blood pressure maintenance and sodium balance in the normal late pregnant rat
Feb 24, 2014
Normal pregnancy is a state marked by avid sodium retention and plasma volume expansion. Insufficient plasma volume expansion results in the compromis...
Renal redox response to normal pregnancy in the rat
Jan 2, 2014
Normal pregnancy involves increased renal sodium reabsorption, metabolism, and oxygen consumption, which can cause increased oxidative stress (OS). OS...
Chronic vasodilation increases renal medullary PDE5A and α-ENaC through independent renin-angiotensin-aldosterone system pathways
Sep 25, 2013
We have previously observed that many of the renal and hemodynamic adaptations seen in normal pregnancy can be induced in virgin female rats by chroni...
Effects of voluntary wheel running on the kidney at baseline and after ischaemia-reperfusion-induced acute kidney injury: a strain difference comparison
Dec 24, 2012
Exercise-induced vascular endothelial adaptations in the kidney are not well understood. Therefore, we investigated the impact of voluntary wheel runn...
Voluntary participation in an active learning exercise leads to a better understanding of physiology
Mar 2, 2011
Students learn best when they are focused and thinking about the subject at hand. To teach physiology, we must offer opportunities for students to act...
Increased renal alpha-epithelial sodium channel (ENAC) protein and increased ENAC activity in normal pregnancy
Aug 4, 2010
Pregnancy-mediated sodium (Na) retention is required to provide an increase in plasma volume for the growing fetus. The mechanisms responsible for thi...