Adaptive remodeling of renal Na+ and K+ transport during pregnancy
Sep 27, 2018
Purpose of review: Renal ion transport undergoes dramatic changes during the course of gestation.
Cardio-Renal Physiology Laboratory, ResearchSalt-sensitive (Rapp) rats from Envigo spontaneously develop accelerated hypertension independent of ovariectomy on a low-sodium diet
Jul 19, 2018
Inbred salt-sensitive (SS) rats developed by John Rapp and distributed by Harlan (SS/JrHsd) were shown to model ovariectomy-induced hypertension... Cardio-Renal Physiology Laboratory, Research
Role of the Renin Angiotensin System in Blood Pressure Allostasis-induced by Severe Food Restriction in Female Fischer rats
Jul 9, 2018
Severe food restriction (FR) is associated with blood pressure (BP) and cardiovascular dysfunction.
Cardio-Renal Physiology Laboratory, ResearchRenal and colonic potassium transporters in the pregnant rat
Feb 1, 2018
Gestational potassium retention, most of which occurs during late pregnancy, is essential for fetal development.
Cardio-Renal Physiology Laboratory, ResearchLoss of Resistance to Angiotensin II-Induced Hypertension in the Jackson Laboratory Recombination-Activating Gene Null Mouse on the C57BL/6J Background
Apr 24, 2017
Resistance to angiotensin II (Ang II)-induced hypertension in T-cell-deficient male mice with a targeted mutation in the recombination-activating... Cardio-Renal Physiology Laboratory, Research
The enigma of continual plasma volume expansion in pregnancy: critical role of the renin-angiotensin-aldosterone system
Oct 5, 2016
Pregnancy is characterized by avid renal sodium retention and plasma volume expansion in the presence of decreased blood pressure.
Cardio-Renal Physiology Laboratory, ResearchThe chloride-bicarbonate exchanger pendrin is increased in the kidney of the pregnant rat
Sep 2, 2015
What is the central question of this study? Pregnancy requires a robust plasma volume expansion driven by renal sodium retention.
Cardio-Renal Physiology Laboratory, ResearchRenal NCC is unchanged in the midpregnant rat and decreased in the late pregnant rat despite avid renal Na+ retention
Apr 29, 2015
Pregnancy is characterized by plasma volume expansion due to Na(+) retention, driven by aldosterone.
Cardio-Renal Physiology Laboratory, ResearchPregnant rats treated with a high-fat/prooxidant Western diet with ANG II and TNF-α are resistant to elevations in blood pressure and renal oxidative stress
Mar 25, 2015
Oxidative stress and inflammation are risk factors for hypertension in pregnancy.
Cardio-Renal Physiology Laboratory, ResearchRenal epithelial sodium channel is critical for blood pressure maintenance and sodium balance in the normal late pregnant rat
Feb 24, 2014
Normal pregnancy is a state marked by avid sodium retention and plasma volume expansion.
Cardio-Renal Physiology Laboratory, Research